Identification of Mutations in Distinct Regions of p85 Alpha in Urothelial Cancer

Bladder cancers commonly show genetic aberrations in the phosphatidylinositol 3-kinase signaling pathway. Here we have screened for mutations in PIK3R1, which encodes p85α, one of the regulatory subunits of PI3K. Two hundred and sixty-four bladder tumours and 41 bladder tumour cell lines were screen...

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Detalles Bibliográficos
Autores principales: Ross, Rebecca L., Burns, Julie E., Taylor, Claire F., Mellor, Paul, Anderson, Deborah H., Knowles, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867501/
https://www.ncbi.nlm.nih.gov/pubmed/24367658
http://dx.doi.org/10.1371/journal.pone.0084411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867501/
https://www.ncbi.nlm.nih.gov/pubmed/24367658
http://dx.doi.org/10.1371/journal.pone.0084411

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