Structure-Activity Relationships of Benzbromarone Metabolites and Derivatives as EYA Inhibitory Anti-Angiogenic Agents

The tyrosine phosphatase activity of the phosphatase-transactivator protein Eyes Absent (EYA) is angiogenic through its roles in endothelial cell migration and tube formation. Benzbromarone, a known anti-gout agent, was previously identified as an inhibitor of EYA with anti-angiogenic properties. He...

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Detalles Bibliográficos
Autores principales: Pandey, Ram Naresh, Wang, Tim Sen, Tadjuidje, Emmanuel, McDonald, Matthew G., Rettie, Allan E., Hegde, Rashmi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867503/
https://www.ncbi.nlm.nih.gov/pubmed/24367676
http://dx.doi.org/10.1371/journal.pone.0084582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867503/
https://www.ncbi.nlm.nih.gov/pubmed/24367676
http://dx.doi.org/10.1371/journal.pone.0084582

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