Cargando…

Multiple HLA Epitopes Contribute to Type 1 Diabetes Susceptibility

Disease susceptibility for type 1 diabetes is strongly associated with the inheritance of specific HLA alleles. However, conventional allele frequency analysis can miss HLA associations because many alleles are rare. In addition, disparate alleles that have similar peptide-binding sites, or shared e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roark, Christina L., Anderson, Kirsten M., Simon, Lucas J., Schuyler, Ronald P., Aubrey, Michael T., Freed, Brian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868045/ https://www.ncbi.nlm.nih.gov/pubmed/24357703 http://dx.doi.org/10.2337/db13-1153

Ejemplares similares

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes
por: Zhao, Lue Ping, et al.
Publicado: (2019)

Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
por: Baig, Sonia, et al.
Publicado: (2020)

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
por: Dimas, Antigone S., et al.
Publicado: (2014)

Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population
por: Hanson, Robert L., et al.
Publicado: (2015)

CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes
por: Vuori, Nadja, et al.
Publicado: (2019)

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
por: Zhao, Lue Ping, et al.
Publicado: (2020)

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
por: Travers, Mary E., et al.
Publicado: (2013)

Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus
por: Blue, Emily K., et al.
Publicado: (2015)

A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes
por: Hanson, Robert L., et al.
Publicado: (2014)

Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population
por: Gamboa-Meléndez, Marco Alberto, et al.
Publicado: (2012)

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
por: Tabassum, Rubina, et al.
Publicado: (2013)

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
por: Hippich, Markus, et al.
Publicado: (2019)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians
por: Chen, Peng, et al.
Publicado: (2014)

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
por: Lane, Jacqueline M., et al.
Publicado: (2016)

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
por: Segrè, Ayellet V., et al.
Publicado: (2015)

Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes
por: Syreeni, Anna, et al.
Publicado: (2019)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins
por: Roshandel, Delnaz, et al.
Publicado: (2016)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population
por: Zhou, Qiulun, et al.
Publicado: (2021)

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
por: Bouchard, Luigi, et al.
Publicado: (2012)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
por: Ge, Yan, et al.
Publicado: (2016)

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid
por: Morieri, Mario Luca, et al.
Publicado: (2020)

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
por: Warren, Liling L., et al.
Publicado: (2012)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Children Can Be Further Stratified Using Expression Patterns of Multiple Genes Implicated in Peripheral Blood Lymphocyte Activation and Function
por: Jin, Yulan, et al.
Publicado: (2014)

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
por: Roberts, Geoffrey P., et al.
Publicado: (2019)

A Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women
por: You, Nai-chieh Y., et al.
Publicado: (2012)

Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources
por: Frohnert, Brigitte I., et al.
Publicado: (2020)

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
por: Chen, Brian H., et al.
Publicado: (2016)

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
por: Billings, Liana K., et al.
Publicado: (2012)

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study
por: Sobrin, Lucia, et al.
Publicado: (2017)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ncsa89cn3hu2st75f4geg9ti29