Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels

Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir channels require interaction of phosphatidyl-4,5-bisphosphate (PIP(2)) at a crystallographically identified binding site, but an additional nonspecific secondary anionic phospholipid (PL(−)) is required to generate high...

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Detalles Bibliográficos
Autores principales: Lee, Sun-Joo, Wang, Shizhen, Borschel, William, Heyman, Sarah, Gyore, Jacob, Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868208/
https://www.ncbi.nlm.nih.gov/pubmed/24270915
http://dx.doi.org/10.1038/ncomms3786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868208/
https://www.ncbi.nlm.nih.gov/pubmed/24270915
http://dx.doi.org/10.1038/ncomms3786

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