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A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice

Diet-induced obesity is a lifestyle-associated medical condition that increases the risk of developing cardiovascular disease, type 2 diabetes and certain types of cancer. Here we report the design of a closed-loop genetic circuit that constantly monitors blood fatty acid levels in the setting of di...

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Detalles Bibliográficos
Autores principales: Rössger, Katrin, Charpin-El-Hamri, Ghislaine, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868331/
https://www.ncbi.nlm.nih.gov/pubmed/24281397
http://dx.doi.org/10.1038/ncomms3825