DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca(2+) concentration in human cancer cells

N,N-Dimethyl-D-erythro-sphingosine (DMS) is known to induce cell apoptosis by specifically inhibiting sphingosine kinase 1 (SPHK1) and modulating the activity of cellular ceramide levels. The present study investigated the effects and the mechanism(s) of action of DMS in human lung cancer cells. We...

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Detalles Bibliográficos
Autores principales: CHEN, KAN, PAN, QIUWEI, GAO, YING, YANG, XINYAN, WANG, SHIBING, PEPPELENBOSCH, MAIKEL P., KONG, XIANGDONG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868491/
https://www.ncbi.nlm.nih.gov/pubmed/24173614
http://dx.doi.org/10.3892/ijmm.2013.1541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868491/
https://www.ncbi.nlm.nih.gov/pubmed/24173614
http://dx.doi.org/10.3892/ijmm.2013.1541

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