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DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca(2+) concentration in human cancer cells
N,N-Dimethyl-D-erythro-sphingosine (DMS) is known to induce cell apoptosis by specifically inhibiting sphingosine kinase 1 (SPHK1) and modulating the activity of cellular ceramide levels. The present study investigated the effects and the mechanism(s) of action of DMS in human lung cancer cells. We...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868491/ https://www.ncbi.nlm.nih.gov/pubmed/24173614 http://dx.doi.org/10.3892/ijmm.2013.1541 |