Cargando…

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion

Herpes simplex virus (HSV) - and herpesviruses in general - encode for a multipartite entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three additional glycoproteins, gH/gL and gB, conserved across the Herpesviridae family and responsible for the execution of f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gianni, Tatiana, Salvioli, Stefano, Chesnokova, Liudmila S., Hutt-Fletcher, Lindsey M., Campadelli-Fiume, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868510/ https://www.ncbi.nlm.nih.gov/pubmed/24367260 http://dx.doi.org/10.1371/journal.ppat.1003806

Ejemplares similares

The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors
por: Gatta, Valentina, et al.
Publicado: (2015)

The Epithelial αvβ3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components
por: Gianni, Tatiana, et al.
Publicado: (2014)

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
por: Wu, Yiquan, et al.
Publicado: (2017)

The Murid Herpesvirus-4 gH/gL Binds to Glycosaminoglycans
por: Gillet, Laurent, et al.
Publicado: (2008)

Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins
por: Petrovic, Biljana, et al.
Publicado: (2017)

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL
por: Chowdary, Tirumala K., et al.
Publicado: (2010)

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex
por: Wussow, Felix, et al.
Publicado: (2014)

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms
por: Fricke, Thomas, et al.
Publicado: (2022)

αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion
por: Vannini, Andrea, et al.
Publicado: (2019)

The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
por: Gillet, Laurent, et al.
Publicado: (2008)

Well Put Together—A Guide to Accessorizing with the Herpesvirus gH/gL Complexes
por: Gonzalez-Del Pino, Gonzalo L., et al.
Publicado: (2022)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
por: Gillet, Laurent, et al.
Publicado: (2008)

Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally
por: Paradowska, Edyta, et al.
Publicado: (2019)

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions
por: Vanarsdall, Adam L., et al.
Publicado: (2016)

Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target
por: Basha, Syed Hussain, et al.
Publicado: (2013)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles
por: Polpitiya Arachchige, Sachith, et al.
Publicado: (2019)

The KGD Motif of Epstein-Barr Virus gH/gL Is Bifunctional, Orchestrating Infection of B Cells and Epithelial Cells
por: Chen, Jia, et al.
Publicado: (2012)

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection
por: Auerbach, Marcy R., et al.
Publicado: (2014)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors
por: Atanasiu, Doina, et al.
Publicado: (2013)

Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B
por: Wang, Bochao, et al.
Publicado: (2020)

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex
por: Wagner, Felicia M., et al.
Publicado: (2013)

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals
por: Mortazavi, Yasaman, et al.
Publicado: (2020)

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
por: Steiger, Katja, et al.
Publicado: (2021)

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies
por: Ciferri, Claudio, et al.
Publicado: (2015)

Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis
por: Sun, Jian, et al.
Publicado: (2018)

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses
por: Menotti, Laura, et al.
Publicado: (2018)

Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma
por: Li, Rui-Chen, et al.
Publicado: (2016)

Dimerization in tailoring uptake efficacy of the HSV-1 derived membranotropic peptide gH625
por: Falanga, Annarita, et al.
Publicado: (2017)

HSV-1 gM and the gK/pUL20 Complex Are Important for the Localization of gD and gH/L to Viral Assembly Sites
por: Lau, Sheung-Yee Kathy, et al.
Publicado: (2015)

Functional analyses of heterotrimeric G protein Gα and Gβ subunits in Gibberella zeae
por: Yu, Hye-Young, et al.
Publicado: (2008)

The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
por: Nogalski, Maciej T., et al.
Publicado: (2013)

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus
por: Großkopf, Anna K., et al.
Publicado: (2018)

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex
por: Ha, Sha, et al.
Publicado: (2017)

In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
por: Vallbracht, Melina, et al.
Publicado: (2021)

Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus
por: Su, Hang, et al.
Publicado: (2021)

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
por: Malhi, Harman, et al.
Publicado: (2022)

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion
por: Atanasiu, Doina, et al.
Publicado: (2023)

Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L(gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α
por: Chowdhury, Sona, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_p02fiq09d57c8eom7kf12cf52i