Detection of Slipped-DNAs at the Trinucleotide Repeats of the Myotonic Dystrophy Type I Disease Locus in Patient Tissues

Slipped-strand DNAs, formed by out-of-register mispairing of repeat units on complementary strands, were proposed over 55 years ago as transient intermediates in repeat length mutations, hypothesized to cause at least 40 neurodegenerative diseases. While slipped-DNAs have been characterized in vitro...

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Detalles Bibliográficos
Autores principales: Axford, Michelle M., Wang, Yuh-Hwa, Nakamori, Masayuki, Zannis-Hadjopoulos, Maria, Thornton, Charles A., Pearson, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868534/
https://www.ncbi.nlm.nih.gov/pubmed/24367268
http://dx.doi.org/10.1371/journal.pgen.1003866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868534/
https://www.ncbi.nlm.nih.gov/pubmed/24367268
http://dx.doi.org/10.1371/journal.pgen.1003866

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