Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart

Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumulation of toxic amyloid-like inclusions. We ha...

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Detalles Bibliográficos
Autores principales: Melkani, Girish C., Trujillo, Adriana S., Ramos, Raul, Bodmer, Rolf, Bernstein, Sanford I., Ocorr, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868535/
https://www.ncbi.nlm.nih.gov/pubmed/24367279
http://dx.doi.org/10.1371/journal.pgen.1004024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868535/
https://www.ncbi.nlm.nih.gov/pubmed/24367279
http://dx.doi.org/10.1371/journal.pgen.1004024

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