Cargando…

Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart

Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumulation of toxic amyloid-like inclusions. We ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melkani, Girish C., Trujillo, Adriana S., Ramos, Raul, Bodmer, Rolf, Bernstein, Sanford I., Ocorr, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868535/ https://www.ncbi.nlm.nih.gov/pubmed/24367279 http://dx.doi.org/10.1371/journal.pgen.1004024

Ejemplares similares

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis
por: Trujillo, Adriana S, et al.
Publicado: (2014)

The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model
por: Melkani, Girish C., et al.
Publicado: (2011)

Genetic Variation for Cardiac Dysfunction in Drosophila
por: Ocorr, Karen A., et al.
Publicado: (2007)

SPARC–Dependent Cardiomyopathy in Drosophila
por: Hartley, Paul S., et al.
Publicado: (2016)

Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy
por: Kronert, William A, et al.
Publicado: (2018)

Complex Genetic Architecture of Cardiac Disease in a Wild Type Inbred Strain of Drosophila melanogaster
por: Zhang, Zhi, et al.
Publicado: (2013)

Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness
por: Wang, Yang, et al.
Publicado: (2012)

Automated evaluation of cardiac contractile dynamics and aging prediction using machine learning in a Drosophila model
por: Pant, Aniket, et al.
Publicado: (2023)

Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease
por: Akasaka, Takeshi, et al.
Publicado: (2020)

Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities
por: Bloemink, Marieke J., et al.
Publicado: (2011)

Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology
por: Walls, Stanley M., et al.
Publicado: (2020)

Expression patterns of cardiac aging in Drosophila
por: Cannon, Leah, et al.
Publicado: (2017)

A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects
por: Suggs, Jennifer A., et al.
Publicado: (2017)

ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism
por: Lim, Hui-Ying, et al.
Publicado: (2014)

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes
por: Ivy, Jessica R., et al.
Publicado: (2015)

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy
por: Na, Jianbo, et al.
Publicado: (2013)

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation
por: Spindler, Stephen R., et al.
Publicado: (2012)

Multiplexin Promotes Heart but Not Aorta Morphogenesis by Polarized Enhancement of Slit/Robo Activity at the Heart Lumen
por: Harpaz, Nofar, et al.
Publicado: (2013)

The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II
por: Bloemink, Marieke J., et al.
Publicado: (2016)

A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster
por: Cammarato, Anthony, et al.
Publicado: (2011)

Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila
por: Walls, Stanley, et al.
Publicado: (2020)

The R369 Myosin Residue within Loop 4 Is Critical for Actin Binding and Muscle Function in Drosophila
por: Trujillo, Adriana S., et al.
Publicado: (2022)

Cellular Mechanisms of Drosophila Heart Morphogenesis
por: Vogler, Georg, et al.
Publicado: (2015)

Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
por: Villanueva, Jesús E., et al.
Publicado: (2019)

Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction
por: Kaushik, Gaurav, et al.
Publicado: (2012)

Author Correction: Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
por: Villanueva, Jesús E., et al.
Publicado: (2020)

Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila
por: Trujillo, Adriana S., et al.
Publicado: (2021)

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2
por: Chang, Kai, et al.
Publicado: (2019)

Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction
por: Diop, Soda Balla, et al.
Publicado: (2012)

Increasing autophagy and blocking Nrf2 suppress laminopathy‐induced age‐dependent cardiac dysfunction and shortened lifespan
por: Bhide, Shruti, et al.
Publicado: (2018)

Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis
por: Windheim, Joseph, et al.
Publicado: (2022)

Probing the polygenic basis of cardiomyopathies in Drosophila
por: Qian, Li, et al.
Publicado: (2012)

Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm
por: Kervadec, Anaïs, et al.
Publicado: (2023)

Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis
por: Zheng, Wenjing, et al.
Publicado: (2020)

Cardiac Amyloidosis
por: Elbdri, Salah, et al.
Publicado: (2021)

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging
por: Nishimura, Mayuko, et al.
Publicado: (2014)

Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment
por: Wu, Yuan‐Kun (Aden), et al.
Publicado: (2022)

Untangling Amyloidosis: Recent Advances in Cardiac Amyloidosis
por: Kim, Darae, et al.
Publicado: (2020)

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations
por: Ocorr, Karen, et al.
Publicado: (2017)

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
por: Roth, Jonathan R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6hng0dah52f6v43g3okb6li7rv