Cargando…

Exposure to Inflammatory Cytokines IL-1β and TNFα Induces Compromise and Death of Astrocytes; Implications for Chronic Neuroinflammation

BACKGROUND: Astrocytes have critical roles in the human CNS in health and disease. They provide trophic support to neurons and are innate-immune cells with keys roles during states-of-inflammation. In addition, they have integral functions associated with maintaining the integrity of the blood-brain...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Kralingen, Christa, Kho, Dan Ting, Costa, Jessica, Angel, Catherine Elizabeth, Graham, E. Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868583/ https://www.ncbi.nlm.nih.gov/pubmed/24367648 http://dx.doi.org/10.1371/journal.pone.0084269

Ejemplares similares

Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro
por: Pamies, David, et al.
Publicado: (2021)

Cytokines in Systemic Lupus Erythematosus—Focus on TNF-α and IL-17
por: Richter, Patricia, et al.
Publicado: (2023)

RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling
por: Yin, Shu, et al.
Publicado: (2023)

IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function
por: Skartsis, Nikolaos, et al.
Publicado: (2021)

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells
por: O’Carroll, Simon J., et al.
Publicado: (2015)

Proinflammatory cytokines IL-6 and TNF-α and the development of inflammation in obese subjects
por: Popko, K, et al.
Publicado: (2010)

Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2
por: Hao, Guohua, et al.
Publicado: (2019)

IL-4, IL-10, TNF-α and IFN-γ Cytokine Levels in Patients with Cystic Echinococcosis and Fascioliasis
por: Beyhan, Yunus Emre, et al.
Publicado: (2022)

Neuroprotection by IFN-γ via astrocyte-secreted IL-6 in acute neuroinflammation
por: Sun, Lijie, et al.
Publicado: (2017)

Inflammatory cytokines IL-1β and TNF-α regulate p75(NTR) expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms
por: Choi, Soyoung, et al.
Publicado: (2009)

TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
por: Tutkun, Lütfiye, et al.
Publicado: (2019)

Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients
por: Umare, Vinod, et al.
Publicado: (2014)

Transcriptomic analyses of primary astrocytes under TNFα treatment
por: Birck, Cindy, et al.
Publicado: (2015)

To Evaluate the Role and Relevance of Cytokines IL-17, IL-18, IL-23 and TNF-α and Their Correlation with Disease Severity in Chronic Urticaria
por: Sharma, Preeti, et al.
Publicado: (2020)

Sex-Mediated Differences in LPS Induced Alterations of TNFα, IL-10 Expression, and Prostaglandin Synthesis in Primary Astrocytes
por: Chistyakov, Dmitry V., et al.
Publicado: (2018)

Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
por: Ignatenko, Olesia, et al.
Publicado: (2022)

Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells
por: Bastidas-Coral, Angela P., et al.
Publicado: (2016)

Exosomes secreted by Blastocystis subtypes affect the expression of proinflammatory and anti-inflammatory cytokines (TNFα, IL-6, IL-10, IL-4)
por: Norouzi, Mojtaba, et al.
Publicado: (2022)

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy
por: Ehrenstein, Michael R., et al.
Publicado: (2004)

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines
por: Giannoni, Paolo, et al.
Publicado: (2020)

Exercise training improves the IL-10/TNF-α cytokine balance in the gastrocnemius of rats with heart failure
por: Calegari, Leonardo, et al.
Publicado: (2018)

The Comparison of the IFN-ɤ, TNF-α and IL-10 Cytokines in Healing and Non-healing Cutaneous Leishmaniasis
por: Taraghian, Mina, et al.
Publicado: (2021)

Elevated IL-12, TNF-α, and TNF-α/IL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion
por: Aninagyei, Enoch, et al.
Publicado: (2020)

Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients
por: Fleischer, Vanessa, et al.
Publicado: (2015)

TNF-α, TNF-β, IL-6, and IL-10 Polymorphisms in Patients with Lung Cancer
por: Seifart, Carola, et al.
Publicado: (2005)

Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy
por: Feng, Songfu, et al.
Publicado: (2018)

IL-10 and TNFα Genotypes in SLE
por: López, Patricia, et al.
Publicado: (2010)

Astrocytic ceramide as possible indicator of neuroinflammation
por: de Wit, Nienke M., et al.
Publicado: (2019)

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19
por: Queiroz, Maria Alice Freitas, et al.
Publicado: (2023)

Evaluation of TNF-α, IL-10 and IL-6 Cytokine Production and Their Correlation with Genotype Variants amongst Tuberculosis Patients and Their Household Contacts
por: Joshi, Lavanya, et al.
Publicado: (2015)

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)
por: Lively, Starlee, et al.
Publicado: (2018)

Inflammatory cytokines TNFα, IL-1β, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades
por: Ishijima, Takashi, et al.
Publicado: (2021)

Neuroinflammation Profiling of Brain Cytokines Following Repeated Blast Exposure
por: Heyburn, Lanier, et al.
Publicado: (2023)

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
por: Wilms, Henrik, et al.
Publicado: (2010)

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
por: Tsarouchas, Themistoklis M., et al.
Publicado: (2018)

Prothrombotic State in Asthma Is Related to Increased Levels of Inflammatory Cytokines, IL-6 and TNFα, in Peripheral Blood
por: Bazan-Socha, Stanislawa, et al.
Publicado: (2017)

Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine
por: Burmeister, Amanda R., et al.
Publicado: (2019)

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α
por: Frisoni, Paolo, et al.
Publicado: (2021)

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons
por: Chaudhuri, Amrita Datta, et al.
Publicado: (2018)

Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn's Disease
por: Dige, Anders, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tncan43915ptlk1p301juaunrj