Overexpression of 14-3-3ζ Promotes Tau Phosphorylation at Ser(262) and Accelerates Proteosomal Degradation of Synaptophysin in Rat Primary Hippocampal Neurons

β-amyloid peptide accumulation, tau hyperphosphorylation, and synapse loss are characteristic neuropathological symptoms of Alzheimer’s disease (AD). Tau hyperphosphorylation is suggested to inhibit the association of tau with microtubules, making microtubules unstable and causing neurodegeneration....

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Detalles Bibliográficos
Autores principales: Qureshi, Hamid Y., Han, Dong, MacDonald, Ryen, Paudel, Hemant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868614/
https://www.ncbi.nlm.nih.gov/pubmed/24367683
http://dx.doi.org/10.1371/journal.pone.0084615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868614/
https://www.ncbi.nlm.nih.gov/pubmed/24367683
http://dx.doi.org/10.1371/journal.pone.0084615

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