Enhancing protein disaggregation restores proteasome activity in aged cells

The activity of the ubiquitin-proteasome system, UPS, declines during aging in several multicellular organisms. The reason behind this decline remains elusive. Here, using yeast as a model system, we show that while the level and potential capacity of the 26S proteasome is maintained in replicativel...

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Detalles Bibliográficos
Autores principales: Andersson, Veronica, Hanzén, Sarah, Liu, Beidong, Molin, Mikael, Nyström, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868723/
https://www.ncbi.nlm.nih.gov/pubmed/24243762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868723/
https://www.ncbi.nlm.nih.gov/pubmed/24243762

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