Structural Implications for Selective Targeting of PARPs

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins. PARPs have important cellular roles that include preserving genomic integrity, telomere maintenance, transcriptional...

Descripción completa

Detalles Bibliográficos
Autores principales: Steffen, Jamin D., Brody, Jonathan R., Armen, Roger S., Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868897/
https://www.ncbi.nlm.nih.gov/pubmed/24392349
http://dx.doi.org/10.3389/fonc.2013.00301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868897/
https://www.ncbi.nlm.nih.gov/pubmed/24392349
http://dx.doi.org/10.3389/fonc.2013.00301

Ejemplares similares