Computational Assay of H7N9 Influenza Neuraminidase Reveals R292K Mutation Reduces Drug Binding Affinity

The emergence of a novel H7N9 avian influenza that infects humans is a serious cause for concern. Of the genome sequences of H7N9 neuraminidase available, one contains a substitution of arginine to lysine at position 292, suggesting a potential for reduced drug binding efficacy. We have performed mo...

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Detalles Bibliográficos
Autores principales: Woods, Christopher J., Malaisree, Maturos, Long, Ben, McIntosh-Smith, Simon, Mulholland, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868970/
https://www.ncbi.nlm.nih.gov/pubmed/24356381
http://dx.doi.org/10.1038/srep03561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868970/
https://www.ncbi.nlm.nih.gov/pubmed/24356381
http://dx.doi.org/10.1038/srep03561

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