Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response

The balance between protective immunity and immunopathology often determines the fate of the virus-infected host. How rapidly virus is cleared is a function of initial viral load, viral replication rate, and efficiency of the immune response. Here, we demonstrate, with three different inocula of lym...

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Detalles Bibliográficos
Autores principales: Cornberg, Markus, Kenney, Laurie L., Chen, Alex T., Waggoner, Stephen N., Kim, Sung-Kwon, Dienes, Hans P., Welsh, Raymond M., Selin, Liisa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869045/
https://www.ncbi.nlm.nih.gov/pubmed/24391647
http://dx.doi.org/10.3389/fimmu.2013.00475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869045/
https://www.ncbi.nlm.nih.gov/pubmed/24391647
http://dx.doi.org/10.3389/fimmu.2013.00475

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