Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specifi...

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Detalles Bibliográficos
Autores principales: Mowers, Jonathan, Uhm, Maeran, Reilly, Shannon M, Simon, Joshua, Leto, Dara, Chiang, Shian-Huey, Chang, Louise, Saltiel, Alan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869376/
https://www.ncbi.nlm.nih.gov/pubmed/24368730
http://dx.doi.org/10.7554/eLife.01119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869376/
https://www.ncbi.nlm.nih.gov/pubmed/24368730
http://dx.doi.org/10.7554/eLife.01119

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