Regulation of CYP3A genes by glucocorticoids in human lung cells

Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung.  CYP3A4, 3A5, and 3A7 e...

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Detalles Bibliográficos
Autores principales: Roberts, Jessica K, Moore, Chad D, Romero, Erin G, Ward, Robert M, Yost, Garold S, Reilly, Christopher A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869485/
https://www.ncbi.nlm.nih.gov/pubmed/24555085
http://dx.doi.org/10.12688/f1000research.2-173.v2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869485/
https://www.ncbi.nlm.nih.gov/pubmed/24555085
http://dx.doi.org/10.12688/f1000research.2-173.v2

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