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Drug Resistance Missense Mutations in Cancer Are Subject to Evolutionary Constraints
Several tumour types are sensitive to deactivation of just one or very few genes that are constantly active in the cancer cells, a phenomenon that is termed ‘oncogene addiction’. Drugs that target the products of those oncogenes can yield a temporary relief, and even complete remission. Unfortunatel...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869674/ https://www.ncbi.nlm.nih.gov/pubmed/24376513 http://dx.doi.org/10.1371/journal.pone.0082059 |