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PARP-14 Binds Specific DNA Sequences to Promote Th2 Cell Gene Expression

PARP-14, a member of the poly ADP-ribose polymerase super family, promotes T helper cell 2 (Th2) differentiation by regulating interleukin-4 (IL-4) and STAT6-dependent transcription. Yet, whether PARP-14 globally impacts gene regulation has not been determined. In this report, using an RNA pol II Ch...

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Detalles Bibliográficos
Autores principales: Riley, Jonathan P., Kulkarni, Aishwarya, Mehrotra, Purvi, Koh, Byunghee, Perumal, Narayanan B., Kaplan, Mark H., Goenka, Shreevrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869773/
https://www.ncbi.nlm.nih.gov/pubmed/24376650
http://dx.doi.org/10.1371/journal.pone.0083127