Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

OBJECTIVE: It has been shown that SOCS-1 plays an important role in the proper control of cytokine/growth factor responses and acts as a tumor suppressor in acute myeloid leukemias. Therefore, the objective of the present study was to evaluate the in vitro effect of treatment with Nutlin-3, a small...

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Detalles Bibliográficos
Autores principales: Tisato, Veronica, Norcio, Alessia, Celeghini, Claudio, Milani, Daniela, Gonelli, Arianna, Secchiero, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2014
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870313/
https://www.ncbi.nlm.nih.gov/pubmed/24473562
http://dx.doi.org/10.6061/clinics/2014(01)10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870313/
https://www.ncbi.nlm.nih.gov/pubmed/24473562
http://dx.doi.org/10.6061/clinics/2014(01)10

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