HIV-1 gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

The humoral immune response following acute HIV-1 infection is delayed and ineffective. The HIV-1 envelope protein gp120 binds to and signals through α(4)β(7) on T cells. We show that gp120 also binds and signals through α(4)β(7) on naïve B cells, resulting in an abortive proliferative response. In...

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Detalles Bibliográficos
Autores principales: Jelicic, Katija, Cimbro, Raffaello, Nawaz, Fatima, Huang, Da Wei, Zheng, Xin, Yang, Jun, Lempicki, Richard A., Pascuccio, Massimiliano, Van Ryk, Donald, Schwing, Catherine, Hiatt, Joseph, Okwara, Noreen, Wei, Danlan, Roby, Gregg, David, Antonio, Hwang, Young, Kehrl, John H., Arthos, James, Cicala, Claudia, Fauci, Anthony S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870659/
https://www.ncbi.nlm.nih.gov/pubmed/24162774
http://dx.doi.org/10.1038/ni.2746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870659/
https://www.ncbi.nlm.nih.gov/pubmed/24162774
http://dx.doi.org/10.1038/ni.2746

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