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Antihyperalgesia by α2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites
Drugs that enhance GABAergic inhibition alleviate inflammatory and neuropathic pain after spinal application. This antihyperalgesia occurs mainly through GABA(A) receptors (GABA(A)Rs) containing α2 subunits (α2-GABA(A)Rs). Previous work indicates that potentiation of these receptors in the spinal co...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870792/ https://www.ncbi.nlm.nih.gov/pubmed/24045508 http://dx.doi.org/10.1038/npp.2013.221 |