Antihyperalgesia by α2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites

Drugs that enhance GABAergic inhibition alleviate inflammatory and neuropathic pain after spinal application. This antihyperalgesia occurs mainly through GABA(A) receptors (GABA(A)Rs) containing α2 subunits (α2-GABA(A)Rs). Previous work indicates that potentiation of these receptors in the spinal co...

Descripción completa

Detalles Bibliográficos
Autores principales: Paul, Jolly, Yévenes, Gonzalo E, Benke, Dietmar, Lio, Alessandra Di, Ralvenius, William T, Witschi, Robert, Scheurer, Louis, Cook, James M, Rudolph, Uwe, Fritschy, Jean-Marc, Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870792/
https://www.ncbi.nlm.nih.gov/pubmed/24045508
http://dx.doi.org/10.1038/npp.2013.221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870792/
https://www.ncbi.nlm.nih.gov/pubmed/24045508
http://dx.doi.org/10.1038/npp.2013.221

Ejemplares similares