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Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr-1 in the Intestinal Epithelial Cells

Na(+)/H(+) exchangers (NHEs) play important roles in regulating internal pH (pH(i)), cell volume and neutral Na(+) absorption in the human intestine. Earlier studies have shown that low extracellular pH (pH(e)) and metabolic acidosis increases the expression and function of NHE1-3 genes. However, tr...

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Detalles Bibliográficos
Autores principales: Muthusamy, Saminathan, Cheng, Ming, Jeong, Jong-Jin, Kumar, Anoop, Dudeja, Pradeep K., Malakooti, Jaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871166/
https://www.ncbi.nlm.nih.gov/pubmed/24376510
http://dx.doi.org/10.1371/journal.pone.0082023