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Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

Epigenetic changes to chromatin are thought to be essential to cell senescence, which is key to tumorigenesis and aging. Although many studies focus on heterochromatin gain, this work demonstrates large-scale unraveling of peri/centromeric satellites, which occurs in all models of human and mouse se...

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Detalles Bibliográficos
Autores principales: Swanson, Eric C., Manning, Benjamin, Zhang, Hong, Lawrence, Jeanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871423/
https://www.ncbi.nlm.nih.gov/pubmed/24344186
http://dx.doi.org/10.1083/jcb.201306073