The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms

The T cell receptor (TCR) triggers the assembly of “SLP-76 microclusters,” which mediate signals required for T cell activation. In addition to regulating integrin activation, we show that Src kinase–associated phosphoprotein of 55 kD (SKAP55) is required for microcluster persistence and movement, j...

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Detalles Bibliográficos
Autores principales: Ophir, Michael J., Liu, Beiyun C., Bunnell, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871428/
https://www.ncbi.nlm.nih.gov/pubmed/24368808
http://dx.doi.org/10.1083/jcb.201305088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871428/
https://www.ncbi.nlm.nih.gov/pubmed/24368808
http://dx.doi.org/10.1083/jcb.201305088

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