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The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms
The T cell receptor (TCR) triggers the assembly of “SLP-76 microclusters,” which mediate signals required for T cell activation. In addition to regulating integrin activation, we show that Src kinase–associated phosphoprotein of 55 kD (SKAP55) is required for microcluster persistence and movement, j...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871428/ https://www.ncbi.nlm.nih.gov/pubmed/24368808 http://dx.doi.org/10.1083/jcb.201305088 |