Heparanase mediates renal dysfunction during early sepsis in mice

Heparanase, a heparan sulfate-specific glucuronidase, mediates the onset of pulmonary neutrophil adhesion and inflammatory lung injury during early sepsis. We hypothesized that glomerular heparanase is similarly activated during sepsis and contributes to septic acute kidney injury (AKI). We induced...

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Detalles Bibliográficos
Autores principales: Lygizos, Melissa I, Yang, Yimu, Altmann, Christopher J, Okamura, Kayo, Hernando, Ana Andres, Perez, Mario J, Smith, Lynelle P, Koyanagi, Daniel E, Gandjeva, Aneta, Bhargava, Rhea, Tuder, Rubin M, Faubel, Sarah, Schmidt, Eric P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871468/
https://www.ncbi.nlm.nih.gov/pubmed/24400155
http://dx.doi.org/10.1002/phy2.153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871468/
https://www.ncbi.nlm.nih.gov/pubmed/24400155
http://dx.doi.org/10.1002/phy2.153

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