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Heparanase mediates renal dysfunction during early sepsis in mice
Heparanase, a heparan sulfate-specific glucuronidase, mediates the onset of pulmonary neutrophil adhesion and inflammatory lung injury during early sepsis. We hypothesized that glomerular heparanase is similarly activated during sepsis and contributes to septic acute kidney injury (AKI). We induced...
Autores principales: | Lygizos, Melissa I, Yang, Yimu, Altmann, Christopher J, Okamura, Kayo, Hernando, Ana Andres, Perez, Mario J, Smith, Lynelle P, Koyanagi, Daniel E, Gandjeva, Aneta, Bhargava, Rhea, Tuder, Rubin M, Faubel, Sarah, Schmidt, Eric P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871468/ https://www.ncbi.nlm.nih.gov/pubmed/24400155 http://dx.doi.org/10.1002/phy2.153 |
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