The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

CLL cell trafficking between blood and tissue compartments is an integral part of the disease process. Idelalisib, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor causes rapid lymph node shrinkage, along with an increase in lymphocytosis, prior to inducing objective responses in CLL patients. Th...

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Detalles Bibliográficos
Autores principales: Fiorcari, Stefania, Brown, Wells S., McIntyre, Bradley W., Estrov, Zeev, Maffei, Rossana, O’Brien, Susan, Sivina, Mariela, Hoellenriegel, Julia, Wierda, William G., Keating, Michael J., Ding, Wei, Kay, Neil E., Lannutti, Brian J., Marasca, Roberto, Burger, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871531/
https://www.ncbi.nlm.nih.gov/pubmed/24376763
http://dx.doi.org/10.1371/journal.pone.0083830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871531/
https://www.ncbi.nlm.nih.gov/pubmed/24376763
http://dx.doi.org/10.1371/journal.pone.0083830

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