Long-Term Gene Therapy with Thrombospondin 2 Inhibits TGF-β Activation, Inflammation and Angiogenesis in Chronic Allograft Nephropathy

We recently identified Thrombospondin-2 (TSP-2) as a regulator of matrix remodelling and inflammation in experimental kidney disease by using TSP-2 null mice and successfully proved TSP-2 overexpression as a therapeutic concept in a short term glomerulonephritis model in the rat. In this current stu...

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Detalles Bibliográficos
Autores principales: Daniel, Christoph, Vogelbacher, Regina, Stief, Andrea, Grigo, Christina, Hugo, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871554/
https://www.ncbi.nlm.nih.gov/pubmed/24376766
http://dx.doi.org/10.1371/journal.pone.0083846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871554/
https://www.ncbi.nlm.nih.gov/pubmed/24376766
http://dx.doi.org/10.1371/journal.pone.0083846

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