Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro

Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purva...

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Detalles Bibliográficos
Autores principales: Cihalova, Daniela, Hofman, Jakub, Ceckova, Martina, Staud, Frantisek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871618/
https://www.ncbi.nlm.nih.gov/pubmed/24376706
http://dx.doi.org/10.1371/journal.pone.0083467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871618/
https://www.ncbi.nlm.nih.gov/pubmed/24376706
http://dx.doi.org/10.1371/journal.pone.0083467

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