A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET)

Effector-induced allosteric transitions in cytochrome P450 3A4 (CYP3A4) were investigated by luminescence resonance energy transfer (LRET) between two SH-reactive probes attached to various pairs of distantly located cysteine residues, namely the double-cysteine mutants CYP3A4(C64/C468), CYP3A4(C377...

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Detalles Bibliográficos
Autores principales: Sineva, Elena V., Rumfeldt, Jessica A. O., Halpert, James R., Davydov, Dmitri R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871636/
https://www.ncbi.nlm.nih.gov/pubmed/24376769
http://dx.doi.org/10.1371/journal.pone.0083898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871636/
https://www.ncbi.nlm.nih.gov/pubmed/24376769
http://dx.doi.org/10.1371/journal.pone.0083898

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