Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients

IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4(+)CD25(hi)FOXP3(+) regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have...

Descripción completa

Detalles Bibliográficos
Autores principales: Cerosaletti, Karen, Schneider, Anya, Schwedhelm, Katharine, Frank, Ian, Tatum, Megan, Wei, Shan, Whalen, Elizabeth, Greenbaum, Carla, Kita, Mariko, Buckner, Jane, Long, S. Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703/
https://www.ncbi.nlm.nih.gov/pubmed/24376757
http://dx.doi.org/10.1371/journal.pone.0083811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871703/
https://www.ncbi.nlm.nih.gov/pubmed/24376757
http://dx.doi.org/10.1371/journal.pone.0083811

Ejemplares similares