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Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS

Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have relative underrepresentation; however, possible tissue and cell differences in mtDNA methylation and relationships to neurodegenerative...

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Detalles Bibliográficos
Autores principales: Wong, Margaret, Gertz, Barry, Chestnut, Barry A., Martin, Lee J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872319/
https://www.ncbi.nlm.nih.gov/pubmed/24399935
http://dx.doi.org/10.3389/fncel.2013.00279