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Activation of Arp2/3 Complex: Addition of the First Subunit of the New Filament by a WASP Protein Triggers Rapid ATP Hydrolysis on Arp2
In response to activation by WASP-family proteins, the Arp2/3 complex nucleates new actin filaments from the sides of preexisting filaments. The Arp2/3-activating (VCA) region of WASP-family proteins binds both the Arp2/3 complex and an actin monomer and the Arp2 and Arp3 subunits of the Arp2/3 comp...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387265/ https://www.ncbi.nlm.nih.gov/pubmed/15094799 http://dx.doi.org/10.1371/journal.pbio.0020091 |