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A single point mutation reveals gating of the human ClC-5 Cl(−)/H(+) antiporter
ClC-5 is a 2Cl(−)/1H(+) antiporter highly expressed in endosomes of proximal tubule cells. It is essential for endocytosis and mutations in ClC-5 cause Dent's disease, potentially leading to renal failure. However, the physiological role of ClC-5 is still unclear. One of the main issues is whet...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Science Inc
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872759/ https://www.ncbi.nlm.nih.gov/pubmed/24099800 http://dx.doi.org/10.1113/jphysiol.2013.260240 |