Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal deficiency of the imprinted gene UBE3A. Individuals with AS suffer from intellectual disability, speech impairment, and motor dysfunction. Currently there is no cure for the disease. Here, we evaluated the phenotypic e...

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Detalles Bibliográficos
Autores principales: Meng, Linyan, Person, Richard Erwin, Huang, Wei, Zhu, Ping Jun, Costa-Mattioli, Mauro, Beaudet, Arthur L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873245/
https://www.ncbi.nlm.nih.gov/pubmed/24385930
http://dx.doi.org/10.1371/journal.pgen.1004039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873245/
https://www.ncbi.nlm.nih.gov/pubmed/24385930
http://dx.doi.org/10.1371/journal.pgen.1004039

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