Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammati...

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Detalles Bibliográficos
Autores principales: Narayanan, Ramesh, Yepuru, Muralimohan, Coss, Christopher C., Wu, Zhongzhi, Bauler, Matthew N., Barrett, Christina M., Mohler, Michael L., Wang, Yun, Kim, Juhyun, Snyder, Linda M., He, Yali, Levy, Nelson, Miller, Duane D., Dalton, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873281/
https://www.ncbi.nlm.nih.gov/pubmed/24386191
http://dx.doi.org/10.1371/journal.pone.0083380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873281/
https://www.ncbi.nlm.nih.gov/pubmed/24386191
http://dx.doi.org/10.1371/journal.pone.0083380

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