Crystal Structures and Molecular Dynamics Simulations of Thermophilic Malate Dehydrogenase Reveal Critical Loop Motion for Co-Substrate Binding

Malate dehydrogenase (MDH) catalyzes the conversion of oxaloacetate and malate by using the NAD/NADH coenzyme system. The system is used as a conjugate for enzyme immunoassays of a wide variety of compounds, such as illegal drugs, drugs used in therapeutic applications and hormones. We elucidated th...

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Detalles Bibliográficos
Autores principales: Hung, Chih-Hung, Hwang, Tzann-Shun, Chang, Yu-Yung, Luo, Huei-Ru, Wu, Szu-Pei, Hsu, Chun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873296/
https://www.ncbi.nlm.nih.gov/pubmed/24386145
http://dx.doi.org/10.1371/journal.pone.0083091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873296/
https://www.ncbi.nlm.nih.gov/pubmed/24386145
http://dx.doi.org/10.1371/journal.pone.0083091

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