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Apelin-13 Inhibits Large-Conductance Ca(2+)-Activated K(+) Channels in Cerebral Artery Smooth Muscle Cells via a PI3-Kinase Dependent Mechanism
Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear. Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in VSM cells are critical regulators of me...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873301/ https://www.ncbi.nlm.nih.gov/pubmed/24386141 http://dx.doi.org/10.1371/journal.pone.0083051 |