Cargando…

Two Distinct Determinants of Ligand Specificity in T1R1/T1R3 (the Umami Taste Receptor)

Umami taste perception in mammals is mediated by a heteromeric complex of two G-protein-coupled receptors, T1R1 and T1R3. T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to l-Glu, whereas mouse T1R1/T1R3 responds more strongly to other l-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toda, Yasuka, Nakagita, Tomoya, Hayakawa, Takashi, Okada, Shinji, Narukawa, Masataka, Imai, Hiroo, Ishimaru, Yoshiro, Misaka, Takumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873546/ https://www.ncbi.nlm.nih.gov/pubmed/24214976 http://dx.doi.org/10.1074/jbc.M113.494443

Ejemplares similares

Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional
por: Toda, Yasuka, et al.
Publicado: (2018)

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
por: Sakurai, Takanobu, et al.
Publicado: (2010)

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
por: Kuo, Taiyi, et al.
Publicado: (2017)

Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition
por: D'Arcy, Sheena, et al.
Publicado: (2010)

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds
por: Yoshida, Ryusuke, et al.
Publicado: (2015)

β(2)-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function
por: Kim, Donghwa, et al.
Publicado: (2016)

Functional Dissection of Adenylate Cyclase R, an Inducer of Spore Encapsulation
por: Chen, Zhi-hui, et al.
Publicado: (2010)

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140
por: Hu, Fang, et al.
Publicado: (2015)

Modulator of Apoptosis 1 (MOAP-1) Is a Tumor Suppressor Protein Linked to the RASSF1A Protein
por: Law, Jennifer, et al.
Publicado: (2015)

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010)

miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
por: Koh, Eun-Hee, et al.
Publicado: (2018)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth
por: Subramanian, Deepa, et al.
Publicado: (2015)

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
por: Oriente, Francesco, et al.
Publicado: (2011)

Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-1 (NEDD4-1) Controls the Sorting of Newly Synthesized Ca(V)1.2 Calcium Channels
por: Rougier, Jean-Sebastien, et al.
Publicado: (2011)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo
por: Kir, Serkan, et al.
Publicado: (2012)

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
por: Fahrner, Marc, et al.
Publicado: (2014)

Modulation of Sweet Taste by Umami Compounds via Sweet Taste Receptor Subunit hT1R2
por: Shim, Jaewon, et al.
Publicado: (2015)

Protein Kinase A Regulatory Subunits in Human Adipose Tissue: Decreased R2B Expression and Activity in Adipocytes From Obese Subjects
por: Mantovani, Giovanna, et al.
Publicado: (2009)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

Target of rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae
por: Bourgoint, Clélia, et al.
Publicado: (2018)

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
por: Tsutsui, Kei, et al.
Publicado: (2016)

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
por: Faraz, Mahmood, et al.
Publicado: (2018)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction
por: Mayle, Sophie, et al.
Publicado: (2014)

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3
por: Martin, Daniel, et al.
Publicado: (2014)

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity
por: Koinuma, Daizo, et al.
Publicado: (2011)

Local Cytosolic Ca(2+) Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca(2+) Entry
por: Shen, Wei-Wei, et al.
Publicado: (2011)

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)
por: Meur, Gargi, et al.
Publicado: (2011)

Ring finger protein 126 (RNF126) suppresses ionizing radiation–induced p53-binding protein 1 (53BP1) focus formation
por: Lee, Nam Soo, et al.
Publicado: (2018)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

Use of Chimeras, Point Mutants, and Molecular Modeling to Map the Antagonist-binding Site of 4,4′,4″,4‴-(Carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic Acid (NF449) at P2X1 Receptors for ATP
por: Farmer, Louise K., et al.
Publicado: (2015)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor
por: Whiteman, Pat, et al.
Publicado: (2013)

Inhibition of the Cardiac Na(+) Channel Nav1.5 by Carbon Monoxide
por: Elies, Jacobo, et al.
Publicado: (2014)

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine
por: Sun, Emily W., et al.
Publicado: (2017)

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ(1–40/42) and Phospho-Tau May Abet Alzheimer Development
por: Sajan, Mini, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ee2aa5dhsdpg7tpbu1bv9n8ebt