Amino Acid Region 1000–1008 of Factor V Is a Dynamic Regulator for the Emergence of Procoagulant Activity

Single chain factor V (fV) circulates as an M(r) 330,000 quiescent pro-cofactor. Removal of the B domain and generation of factor Va (fVa) are vital for procoagulant activity. We investigated the role of the basic amino acid region 1000–1008 within the B domain of fV by constructing a recombinant mu...

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Detalles Bibliográficos
Autores principales: Wiencek, Joesph R., Na, Mahesheema, Hirbawi, Jamila, Kalafatis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873559/
https://www.ncbi.nlm.nih.gov/pubmed/24178294
http://dx.doi.org/10.1074/jbc.M113.462374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873559/
https://www.ncbi.nlm.nih.gov/pubmed/24178294
http://dx.doi.org/10.1074/jbc.M113.462374

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