Cargando…

Amino Acid Region 1000–1008 of Factor V Is a Dynamic Regulator for the Emergence of Procoagulant Activity

Single chain factor V (fV) circulates as an M(r) 330,000 quiescent pro-cofactor. Removal of the B domain and generation of factor Va (fVa) are vital for procoagulant activity. We investigated the role of the basic amino acid region 1000–1008 within the B domain of fV by constructing a recombinant mu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiencek, Joesph R., Na, Mahesheema, Hirbawi, Jamila, Kalafatis, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873559/ https://www.ncbi.nlm.nih.gov/pubmed/24178294 http://dx.doi.org/10.1074/jbc.M113.462374

Ejemplares similares

A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2
por: Wong, Swee Kee, et al.
Publicado: (2004)

Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY
por: Hong, Bum Soo, et al.
Publicado: (2010)

Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors
por: Blundell, Patricia A., et al.
Publicado: (2017)

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain
por: Carafoli, Federico, et al.
Publicado: (2009)

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi
por: Upadhyay, Abhishek, et al.
Publicado: (2008)

The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking
por: Fukutani, Yosuke, et al.
Publicado: (2019)

Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase
por: Jørgensen, René, et al.
Publicado: (2013)

Plasticity of Human Protein Disulfide Isomerase: EVIDENCE FOR MOBILITY AROUND THE X-LINKER REGION AND ITS FUNCTIONAL SIGNIFICANCE
por: Wang, Chao, et al.
Publicado: (2010)

The C-terminal region of the plasmid partitioning protein TubY is a tetramer that can bind membranes and DNA
por: Hayashi, Ikuko
Publicado: (2020)

Low Resolution Structure and Dynamics of a Colicin-Receptor Complex Determined by Neutron Scattering
por: Clifton, Luke A., et al.
Publicado: (2012)

Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
por: Preller, Matthias, et al.
Publicado: (2011)

An Undecided Coiled Coil: THE LEUCINE ZIPPER OF Nek2 KINASE EXHIBITS ATYPICAL CONFORMATIONAL EXCHANGE DYNAMICS
por: Croasdale, Rebecca, et al.
Publicado: (2011)

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering
por: Cheng, Cecilia Y., et al.
Publicado: (2009)

Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl Isomerases
por: Jaremko, Łukasz, et al.
Publicado: (2011)

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange
por: Rispens, Theo, et al.
Publicado: (2014)

Transmission of Stability Information through the N-domain of Tropomyosin Is Interrupted by a Stabilizing Mutation (A109L) in the Hydrophobic Core of the Stability Control Region (Residues 97–118)
por: Kirwan, J. Paul, et al.
Publicado: (2014)

Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane
por: de Oliveira, Guilherme A. P., et al.
Publicado: (2013)

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability
por: Houliston, R. Scott, et al.
Publicado: (2017)

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2005)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
por: Gelinas, Amy D., et al.
Publicado: (2014)

Structural and Mechanistic Insight into the Listeria monocytogenes Two-enzyme Lipoteichoic Acid Synthesis System
por: Campeotto, Ivan, et al.
Publicado: (2014)

Structural and Functional Studies of a Newly Grouped Haloquadratum walsbyi Bacteriorhodopsin Reveal the Acid-resistant Light-driven Proton Pumping Activity
por: Hsu, Min-Feng, et al.
Publicado: (2015)

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain
por: Salvage, Samantha C., et al.
Publicado: (2019)

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase
por: Kim, Hyoun Sook, et al.
Publicado: (2015)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
por: Cunningham, Christian N., et al.
Publicado: (2008)

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System
por: Lewis, Melanie J., et al.
Publicado: (2008)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
por: Alexandrov, Ilya M., et al.
Publicado: (2008)

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
por: Grummitt, Charles G., et al.
Publicado: (2008)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance
por: Ling, Jun, et al.
Publicado: (2008)

Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes: MECHANISTIC IMPLICATIONS FOR ACTIVATION AND TRANSLOCATION
por: Kosloff, Mickey, et al.
Publicado: (2008)

Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE
por: Stoddart, Cheryl A., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_16kjaofu6dhsalb8sbtknc6ar3