A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1

The Slx5/Slx8 heterodimer constitutes a SUMO-targeted ubiquitin ligase (STUbL) with an important role in SUMO-targeted degradation and SUMO-dependent signaling. This STUbL relies on SUMO-interacting motifs in Slx5 to aid in substrate targeting and carboxy-terminal RING domains in both Slx5 and Slx8...

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Detalles Bibliográficos
Autores principales: Westerbeck, Jason W., Pasupala, Nagesh, Guillotte, Mark, Szymanski, Eva, Matson, Brooke C., Esteban, Cecilia, Kerscher, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873881/
https://www.ncbi.nlm.nih.gov/pubmed/24196836
http://dx.doi.org/10.1091/mbc.E13-05-0291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873881/
https://www.ncbi.nlm.nih.gov/pubmed/24196836
http://dx.doi.org/10.1091/mbc.E13-05-0291

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