Loss of Canonical Smad4 Signaling Promotes KRAS Driven Malignant Transformation of Human Pancreatic Duct Epithelial Cells and Metastasis

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death in North America. Activating KRAS mutations and Smad4 loss occur in approximately 90% and 55% of PDAC, respectively. While their roles in the early stages of PDAC development have been confirmed in genetically mo...

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Detalles Bibliográficos
Autores principales: Leung, Lisa, Radulovich, Nikolina, Zhu, Chang-Qi, Wang, Dennis, To, Christine, Ibrahimov, Emin, Tsao, Ming-Sound
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873993/
https://www.ncbi.nlm.nih.gov/pubmed/24386371
http://dx.doi.org/10.1371/journal.pone.0084366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873993/
https://www.ncbi.nlm.nih.gov/pubmed/24386371
http://dx.doi.org/10.1371/journal.pone.0084366

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