The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment

Lgr5 is a membrane protein related to G protein-coupled receptors (GPCR)s whose expression identifies stem cells in multiple tissues and is strongly correlated with cancer. Despite the recent identification of endogenous ligands for Lgr5, its mode of signaling remains enigmatic. The ability to coupl...

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Detalles Bibliográficos
Autores principales: Snyder, Joshua C., Rochelle, Lauren K., Barak, Larry S., Caron, Marc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873998/
https://www.ncbi.nlm.nih.gov/pubmed/24386388
http://dx.doi.org/10.1371/journal.pone.0084476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873998/
https://www.ncbi.nlm.nih.gov/pubmed/24386388
http://dx.doi.org/10.1371/journal.pone.0084476

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