Cargando…

Tyrosine Phosphorylation Allows Integration of Multiple Signaling Inputs by IKKβ

Signaling regulated by NFκB and related transcription factors is centrally important to many inflammatory and autoimmune diseases, cancer, and stress responses. The kinase that directly regulates the canonical NFκB transcriptional pathway, Inhibitor of κB kinase β (IKKβ), undergoes activation by Ser...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meyer, April N., Drafahl, Kristine A., McAndrew, Christopher W., Gilda, Jennifer E., Gallo, Leandro H., Haas, Martin, Brill, Laurence M., Donoghue, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873999/ https://www.ncbi.nlm.nih.gov/pubmed/24386391 http://dx.doi.org/10.1371/journal.pone.0084497

Ejemplares similares

The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling
por: Drafahl, Kristine A., et al.
Publicado: (2010)

Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling
por: Gallo, Leandro H, et al.
Publicado: (2014)

Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation
por: Meyer, April N., et al.
Publicado: (2018)

Novel Phosphorylations of IKKγ/NEMO
por: Lee, Sun Hwa, et al.
Publicado: (2012)

Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer
por: Zhong, Chenxi, et al.
Publicado: (2023)

FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
por: Saxena, Kritika, et al.
Publicado: (2023)

TRAF5-mediated Tax ubiquitination modulates IKK phosphorylation but not binding to NEMO
por: Bonnet, Amandine, et al.
Publicado: (2014)

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
por: Prescott, Jack A., et al.
Publicado: (2018)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
por: Thompson, Leslie Michels, et al.
Publicado: (2009)

IKK-mediated CYLD phosphorylation and cellular redox activity
por: Erol, Adnan
Publicado: (2022)

Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFβ-Activated Kinase 1 Tyrosine Phosphorylation and NFκB Signaling in Multiple Myeloma and Bladder Cancer
por: Salazar, Lisa, et al.
Publicado: (2014)

Shikonin Suppresses Human T Lymphocyte Activation through Inhibition of IKKβ Activity and JNK Phosphorylation
por: Li, Ting, et al.
Publicado: (2013)

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3
por: Reid, Michael A., et al.
Publicado: (2016)

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
por: Zhang, Jiazhen, et al.
Publicado: (2014)

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
por: Khoshnan, Ali, et al.
Publicado: (2009)

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation
por: Chi, Jyun-Ni, et al.
Publicado: (2022)

Generalizing Koopman Theory to Allow for Inputs and Control
por: Proctory, Joshua L., et al.
Publicado: (2018)

VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer
por: Chen, Jionghuang, et al.
Publicado: (2022)

IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα
por: Liu, Juan, et al.
Publicado: (2022)

Context-Dependent Role of IKKβ in Cancer
por: Page, Angustias, et al.
Publicado: (2017)

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
por: Ho, Catherine M. K., et al.
Publicado: (2016)

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis
por: Bakovic, Allison, et al.
Publicado: (2020)

Sensory input attenuation allows predictive sexual response in yeast
por: Banderas, Alvaro, et al.
Publicado: (2016)

Transmembrane Domain Sequence Requirements for Activation of the p185(c-neu) Receptor Tyrosine Kinase
por: Chen, Lucinda I., et al.
Publicado: (1997)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

Hit identification of IKKβ natural product inhibitor
por: Leung, Chung-Hang, et al.
Publicado: (2013)

IKKβ links vascular inflammation to obesity and atherosclerosis
por: Sui, Yipeng, et al.
Publicado: (2014)

IKKβ is required for the formation of the NLRP3 inflammasome
por: Nanda, Sambit K, et al.
Publicado: (2021)

Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ
por: Gan, Jiali, et al.
Publicado: (2023)

Crystal structure of inhibitor of κB kinase β (IKKβ)
por: Xu, Guozhou, et al.
Publicado: (2011)

Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling
por: Xing, Fei, et al.
Publicado: (2016)

The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
por: Moser, Bernhard, et al.
Publicado: (2021)

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway
por: Adli, Mazhar, et al.
Publicado: (2010)

Antinociceptive Effect of Tetrandrine on LPS-Induced Hyperalgesia via the Inhibition of IKKβ Phosphorylation and the COX-2/PGE(2) Pathway in Mice
por: Zhao, Hengguang, et al.
Publicado: (2014)

Trichothecin Induces Cell Death in NF-κB Constitutively Activated Human Cancer Cells via Inhibition of IKKβ Phosphorylation
por: Su, Jia, et al.
Publicado: (2013)

Feedforward Inhibition Allows Input Summation to Vary in Recurrent Cortical Networks
por: Histed, Mark H.
Publicado: (2018)

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells
por: Drube, Sebastian, et al.
Publicado: (2015)

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis
por: Li, Zhi-Wei, et al.
Publicado: (1999)

The Role of IKKβ in Venezuelan Equine Encephalitis Virus Infection
por: Amaya, Moushimi, et al.
Publicado: (2014)

Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases
por: Hernandez, Rebecca, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u2hbsviq6aak46fd6ld4s6qb1j